Background: Axillary surgery has revolutionized in recent years with the use of sentinel node biopsy to assess axillary node involvement, thus preventing patients from undergoing unnecessary axillary clearance, which can be associated with morbidities. Subjects & Methods: this study was conducted on 50 cases; during either conservative breast surgery or modified radical mastectomy, the lateral group of axillary nodes (lying lateral to the thoracodorsal pedicle) was sent separately for pathological assessment (paraffin). Results: Our study is Descriptive Prospective Study conducted on 50 female patients with breast cancer, surgeries were done at Ain Shams and Aswan universities' Hospitals from 2018 to 2019. The lateral group axillary LNs were separately resected and sent for pathological examination together with the rest of resected specimen. Patients underwent complete ALND at the time of definitive surgery. Conclusion: Surgical resection is the mainstay of treatment of non-metastatic breast cancer, and complete surgical resection is necessary for optimal local control. In a lower middle income country like Egypt, there is late stage at presentation and a higher incidence of axillary nodal involvement. We recommend routine axillary clearance up including the lateral group in node-positive axilla, especially when multiple lower-level axillary nodes are involved while in node negative lower level axillary nodes the lateral group should not be included in dissection, this will reduce postoperative complications, especially lymphedema of upper limb. However, more studies on more number of patients are required for proper statistical significance. Key words: Breast cancer, lateral group of axillary LN, Axillary LN, post axillary LN dissection complications, anatomy of the breast.