Background: Diabetes is an increasing urgent global health issue, with an increasing prevalence in those aged 65 or over. Diabetic foot ulcer (DFU) is one of the very important but most neglected complications of diabetes that affect up to 15 % of diabetic patients who are caused by an imbalance between excessive pressure on the soul of the foot and repetitive stress from walking. DFUs can become infected and lead to osteomyelitis, cellulitis and even amputation that increase the morbidity, mortality and very high cost of the health care system. The management of DFUs represents a major clinical challenge, and there remains the continuing uncertainty concerning optimal approaches to management. The aim of this present analysis was to follow a cohort of patients with diabetes in clinical practice from initial presentation of a DFU to evaluate patient management by Hyperoil™. Methods: 12 patients with DFU were asked to attend to the Wound Care Units (WCU) of Zagazig University Hospital between December 2016 and December 2018 followed a standardized diagnostic/ therapeutic scheme to manage the diabetes and coexisting conditions. All DFUs were treated with Hyperoil™ at home, when diabetes was well compensated at WCU. Changes in the HbA1c, blood pressure and pain have been evaluated by using the paired t-test. Results: All the 12 patients recovered their DFUs 2 to 10 months after starting the Hyperoil™. During this period, the HbA1c and pain improved due to DFUs disappeared in all patients. Furthermore, the hypertension was better compensated. Conclusion: According to the results obtained from the present study, it seems that using Hyperoil™ for advanced DFUs, together with tight diabetes control, might be a cheap and effective new option for the home management of advanced DFUs. Keywords: Diabetic foot ulcer; Hyperoil™; Hypericum perforatum; Azadirachta indica; Home wound care.