Ahmed Salah Arafa *, Ahmed yehia , Alaa fiad
1Magdy Salah El-Din Hussain, 1Hisham Wefky Anwar, 2Mostafa Mahmoud El Nakib, 1Amr Essam Mosaad*
Doaa Ahmed Mansour M.D., FRCS Eng
Moutaz Ragab1,Mohamed Hamed Abouelfadl1, Mahmoud M. Marei 1
Moutaz Ragab, Mahmoud M. Marei ,Mohamed Hamed Abouelfadl
Wadie Boshra MD, MRCS, Mohammed Attia Elsayed MD, Ahmed S. M. Omar MD.
Mahmoud Alhussinia, M. Ashraf Balbaab, Ahmed Tarek Awada, Tamer Abdelbakia
Ahmed El-Gendi1, Mohamed El-Shafei2, Essam Bedewy3
Elsobky A, MD
Ahmed Sawaby1, Islam Atta2, Amr El Abd3,Mohsen Ahmed Abdelmohsen4
Ayman M. A. Osman1 MD, MRCS (Eng); Hytham H. Mohey1 M.Sc.; Ahmed M. Ghobashy1 MD
Nezar A. Abo Halawa1*, Ahmed El-Abd Ahmed2, Sawsan A. Elkhateeb3, Galal H. Galal3
Nezar A. Abo Halawa1*, Mohamed Yousef Batikhe2
Wadie Boshra MD, MRCS, Abdallah Hamed Ibrahim Khalil MD, Fawzy Salah Fawzy MD, MRCS
Hussein Ali Mustafa Abdel-Motaleb, Mohammed Ahmed Mohammed Ismail, Islam Mohamed Nabil Atta & Ahmed Mohammed Ahmed Abdel-Rahim*
Reem Mohamed Ali Abd El Reheem El Masry1, Sameh Abd Allah Maaty2, Anwar A. El Shenawy3, Fawzy Salah Fawzy2
Bleomycin Sclerotherapy for Management of Cervicofacial and Axillary Lymphatic Malformations in Children
Background and Aim: Lymphatic malformationscan result in severe functional and aesthetic disorders,
due to their progressive growth and affinity to occur in challenging anatomical regions as the head and
neck region and the axilla. Intralesional sclerotherapy may serve as a single treatment or as an adjunct to
surgery.This study presents our early experience with intralesional bleomycin injection in the management
of axillary and cervicofacial Lymphatic malformations, over an initial period of 12 months. Methods: This
prospective study was conductedat the department of Pediatric Surgery of Cairo University Specialized
Pediatric Hospital (CUSPH) and included 8 patients whopresented with lymphatic malformations and were
all treated with intralesional bleomycin injection. The dose of bleomycin inject was adjusted to 0.5
IU/kg/injection, with 4-weeks intervals, for 3 – 5 cycles. Results: The median age at inclusion and initiation
of treatment was 3.2 years.The average number of sessions was 3.5 ± 0.5. Overall, a satisfactory response
was detected in 87.5% of the cases (n = 7), among them one case had recurrence. No systemic adverse
effects were noted. Conclusion: Intralesional Bleomycin injection is a safe and effective modality for
treating cervicofacial and axillary lymphatic malformations in the pediatric age group.
Keywords: Bleomycin; Sclerotherapy; Intralesional Injection; LymphaticMalformations.