A prospective study aimed to evaluate the role of subintimal angioplasty in recanalization of TASC B&C lesions of superficial femoral artery, regarding the feasibility, the durability and the complications. Fifty seven patients with femoropopliteal occlusive disease were subjected to percutaneous angioplasty either transluminal or subintimal. Patients were followed up both clinically and by duplex scanning at 1,6and12 months after the procedure. Patient and Method: Among of the 57 patients 26 had percutaneous transluminal angioplasty (PTA) while 31 had subintimal angioplasty (SIA). Lesions were TASC B in 20 cases and TASC C in 37 cases. Diabetes was the main co-morbidity in 41cases (72%). Gangrene was the main presentation in 24cases (42.1%). Calcifications were present in 23cases (40%). Single distal runoff was present in 21cases (36.8%). Results: Patency rate after one year of follow up as determined by clinical evaluation was 85.1%,83.3% in SIA and PTA cases respectively whereas duplex study showed popliteal triphasic flow in 85.1%,62.2% in SIA and PTA cases respectively. At the end of one year follow up, Reocclusion of the SFA occurred in sixteen patients, Twelve (75%) of them were diabetics and seven (43.7) of them had heavy SFA calcifications. Eleven of occluded SFA cases had only one distal run off vessel. Conclusion: We recommend SIA to be considered in treatment of SFA lesions especially after failure of translumial crossing and with long heavy calcified ones. SIA is technically feasible, safe, and provides satisfactory revascularization with nearly same results as percutaneous angioplasty (PTA). Calcification is one of the intra operative factors that affects technical difficulty and again long term ( one year or more ) patency especially in the SIA. Keywords: Subintimal angioplasty, superficial femoral artery, TASC B&C.. .