Background: The liver is one of the common organs to be injuried in abdominal trauma. Emergency laparotomy must be done in the patients have major hepatic trauma with hemodynamic instability . Liver resection is one of methods of management of major hepatic trauma. Objective : To assess the role of liver resection in the management of major liver trauma. Patients and methods: Prospective study of forty cases of major hepatic trauma admitted and managed at Trauma Unit, Assiut University Hospitals between (October 2010-May 2015). Follow up every six months for one and half years. The liver injuries were graded according to the criteria published by the American Association for Surgery of Trauma Organ Injury Scaling committee (AAST) based on the most accurate assessment by laparotomy . Results: Forty patients were explored. Anatomical liver resection done in 8(20%) patients, right hepatectomy in 2(5%) patients, right posterior segmentectomy in 2(5%) patients , left hepatectomy in one (2.5%) patient and left lateral segmentectomy in 3(7.5%) patients. Non anatomical liver resection done in 32(80%) patients. Complications developed in 15(37.5%) patients and mortality of six(15%) patients, four of them died from causes directly related to the liver injury. Two patients died from associated other injuries. Conclusion: Liver resections are effective methods in the management of major hepatic trauma. Keywords: Major hepatic trauma, anatomical liver resection, non anatomical liver resection.