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    • Changes in Level of Ghrelin Post Laparoscopic Sleeve Gastrectomy

    Mostafa A. Elshazli, Mohamed D. Sarhan, Ahmed AbdAl Aziz, Mohamed.H.Khattab
    The Department of General Surgery, Faculty of Medicine , Cairo University

    Background: Although sleeve gastrectomy classified as a restrictive procedure in treatment of morbid obesity, it seems to be more than just a mechanicalbarrier to food consumption because the removal of the gastric fundusand part of the body of the stomach. as the fundus the main source of ghrelin hormone , sleeve gastrectomy results in a significant reductionof serum ghrelin levels and alterations in gastric emptying. The aim of the study is to detect the effect of laparoscopic sleeve gastrectomy on the level of ghrelin hormone and its role in weight loss, and to detect a correlation between EBWL and drop in ghrelin hormone level. Methods: The study included 30 morbidly obese patients with BMI from 46.2 to 62.2 Kg/m2 with obesity related comorbidities and had failed trials of conservative management , all of them underwent LSG and the ghrelin level was measured preoperatively at the day of the admission then after 1 month of the operation. Results: In the present study , the drop in the body weight 1 month after sleeve gastrectomy was 9.3%, the drop in ghrelin hormone level was 21.25%. Conclusion: the decrease in the appetite of all patients indicates that the resection of the main source of ghrelin hormone play an important role in the postoperative weight loss. However no correlation was found between the percentage of EBWL and the percentage of ghrelin hormone drop 1 month following laparoscopic sleeve gastrectomy. Keywords: Key words : stomach - ghrelin- sleeve gastrectomy.

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