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    Ahmed Gamal Eldin Fouad¹, Ahmed Faraghaly¹, Ahmed Elmarakby¹, Fatma Zeinhom²
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    1Amr Saleh El Bahaey, 2Ahmed Balboula
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    Fouad S. Fouad1 and Abdelrahman Mohamed2
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    1Mohamed Salama, 1Heba G.M. Mahmoud, 2Marwa Nabil, 1Mohamed Hassan
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    1Hebatallah G.M. Mahmoud, 1Mohamed Salama, 1John Wahib, 2Salem Eid, 1Omaya Nassar
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    Wael Ghanem
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    Salah M. Raslan MD and Hany M. Elbarbary MD, FRCS, FACS
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    Hamdy A. Elhady
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    • Clinicopathologic study of Primary Gastric Lymphoma and its Outcome: NCI Experience

    1Mohamed Salama, 1Heba G.M. Mahmoud, 2Marwa Nabil, 1Mohamed Hassan
    1Department of Surgical Oncology, National Cancer Institute 2Department of Medical Oncology, National Cancer Institute

    Background: The stomach is the most common site of extra nodal lymphoma, In Western countries 60% of primary gastrointestinal lymphomas affect the stomach which is considered to be the most common site of extra-nodal lymphomas, with high incidence of non- Hodgkin's type, mostly of mucosa-associated lymphoid tissue (MALT) lymphoma. Objective: To review the demographic, clinicopathological features, management and outcome of primary gastric lymphoma (PGL). Patients and Methods: A total number of 115 patients diagnosed with primary gastric lymphoma in the National Cancer Institute in Cairo, between January 2008 and December 2014 were included. Results: The study, included 52 females (45.2%) and 63 males (54.8%). Epigastric pain and dyspepsia were the most common presenting symptoms. Ulcerative tumor type was the most common morphology in 56 patients (48.7%). Chemotherapy and radiotherapy were the main line of treatment in 94 cases (81.7%) and 21 cases (18.3%) treated with surgery, chemotherapy and radiotherapy. Local recurrence, bleeding and obstruction were the most common complications. The mean overall survival in patients treated with chemo-radiotherapy was 63.75 months. Overall survival at 1 year, 2 years and 5 years were 86.2%, 81.9% and 51.9% respectively. The mean overall survival in Patients treated with surgery was 85.37 months with overall survival at 1 year, 2 years and 5 years were 95.2%, 95.2% and 79.5% respectively. Conclusion: Treatment for primary gastric lymphomas is still controversial. Surgical intervention versus systemic treatment must be based on the characteristics of each individual patient. Key words: Gastrectomy, Extra nodal Lymphoma, Mucosa-associated lymphoid tissue (MALT) Lymphoma.

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