Background: Peptic ulcer perforation continues to be a major surgical problem. In this study, risk factors that influence morbidity and mortality in perforated peptic ulcer disease were examined. Objective: The aim of this study is to assess the usefulness of the prognostic factors in terms of morbidity and mortality in the treatment of perforated duodenal ulcer patient. Patients and Methods: The study is comprised of patients who presented with peptic ulcer perforation between July 2014 and July 2015 in the department of surgery in Aswan University. Data regarding age, gender, complaints, time elapsed between onset of symptoms and hospital admission, physical examination findings, co-morbid diseases, laboratory and imaging findings, morbidity and mortality were recorded. The study group included 82(82.0%) male and 18 (18%) female patients. The mean age was 54.34±10.45 (18-78) years. Results: The results of this study showed that the most common cause of mortality was cardiovascular failure. Mortality was observed in 8 patients (8.0%). 37 patients (37.0%) had complications. The most common complication was wound infection. Analysis revealed age over 50 years, presence of co-morbidities as independent risk factors for morbidity. Age over 50 years, time to admission and purulent peritoneal fluid were detected as independent risk factors for mortality. Conclusions: We can conclude that the early diagnosis and proper treatment are important in patients presenting with peptic ulcer perforation.