Background: Reoperation following breast conservative surgery for breast cancer patients is not uncommon. Patients who undergo breast-conserving surgery (BCS) may require reoperation to obtain clear margins, which causes delays in adjuvant treatment and poor aesthetic results. However, patient and treatment-related factors associated with re-excision are not well defined .The aim of this study was to evaluate factors affecting reoperation rate of breast conservative surgery. Methods :We surveyed all women undergoing breast conserving surgery between March 2011 to July 2015 at Ain Shams University Hospitals and 2 private hospitals in Jeddah regard their breast disease (n =218). The medical records were reviewed to determine the rate of reoperations, which was done following BCS, and to obtain patient age, tumor size, radiological findings and tumor pathology. Results: In this study, 74.4% of women required only breast conservative surgery once, and 25.6% required reoperation following an initial attempt at BCS where 76.8% of them required re-excision lumpectomy and 23.2% required a mastectomy. Factors significantly correlated with reoperation post breast conservative surgery were the ductal pathology, tumor size, and multicentric or multifocal tumor. Conclusions: Re-operation is not uncommon, and is significantly correlated with ductal pathology, tumor size and multicentric or multifocal tumor as radiological findings. Attention to these risk factors can improve the quality of care delivered to BCS patients by decreasing the cost and morbidity associated with multiple re-excision procedures. Keywords: Breast-conserving surgery-Reoperation, Breast cancer.