Objective: This study was done to evaluate the efficacy of endovenous angioplasty & stenting as a primary choice for the management of chronic venous insufficiency due to iliocaval obstruction. Methods: This is a prospective study of post-thrombotic patients with iliofemoral obstruction was conducted at Ain Shams University and Health Insurance hospitals From March 2014 to November 2016. Duplexultrasound and CT venography were performed in PTS patients with chronic venous insufficiency. Post-thrombotic syndrome (PTS) with ilio-femoral vein obstruction (Villalta score >10) was diagnosed in 20 patients with percutaneousapproach was performed in all patients. Patency rates and complications were analyzed by duplex ultrasound. Clinical outcomewas scored by Venous Clinical Severity Score (VCSS), Villalta scale, and venous claudication rates. In addition, Venous Disability Score (VDS) has been used to score the functional outcome. Results: Percutaneous endo-venous recanalization was successful in 18 of 20 patients (90%) without major complications.mean age was (38.34±8.20) years, range (26-57), Male/Female ratio (3:1), Lt/Rt ratio (5.6:1), The mean duration of PTS symptoms was (28.75±15.14) months (range 6-75 months). Follow up period was 12 month. Cumulative primary, assisted primary patency rates at 1 year were 90%, and 100%, respectively. VCSS and Villalta scores were significantly improved at the last follow up.Venous disability scores demonstrated excellent functional recovery at 12 months follow up. Venous claudication totally subsided in 77.8% and ulcer healing achieved in 71.4% of patients at the end of follow up. Conclusions: Endo-venous therapy is a safe, effective, and feasible method to correct the ilio-femoral obstruction of PTS. It showed favorable short-termclinical and functional outcomes and showed patency rates comparable with previous studies.