Introduction: Peripheral arterial disease (PAD) is a major world-wide health problem. It affects about 12%–14% of the population. The international consensus to define chronic limb threatening ischemia (CLTI) is that any patient with chronic ischemic rest pain, ulcers, or gangrene for more than two weeks with proven PAD. Aim of the Work: To assess the outcome of target vessel revascularization according to angiosome concept on the healing process of ischemic diabetic foot ulcers. Patients and Methods: This is a prospective study conducted at Ain Shams University Hospitals and Nasser institute Hospital in Cairo on 45 patients complaining CLTI in the form of ulcer &/or gangrene. The patients of successful angioplasty were classified into three groups. Group (A) direct revasularization, group (B) indirect revascularization and group (C) combined revascularization. Results: During the assessment of the patients of our study after 6 months of continuous follow up, we found that the healing rate of the patients who underwent direct revascularization (DR), indirect revascularization (ID) and combined revascularization (CR) were (91.67%), (75%) and (92.86%) respectively (p=0.769). Conclusion: Angioplasty of more than one tibial vessel including the target vessel has the best results and more preferable. Direct revascularization of the target artery depending on angiosome model leads to better wound healing rates than indirect revascularization. Key words: Tibial vessel revascularization, diabetic foot, angiosomes.