Introduction: Laparoscopic cholecystectomy is the procedure of choice for treating symptomatic gallstone disease and it is a procedure from the most commonly performed procedures by surgeons. Sometimes, it is challenging and takes much more time even sometimes has to be turned into an open surgery due to some difficulties faced while undergoing the procedure. Purpose: Evaluation of the validity and accuracy of Randhawa and Pujahari preoperative grading scoring system in prediction of difficult laparoscopic cholecystectomy in Egyptian population. Methods and materials: This is a prospective observational study that has been conducted in general surgery department, Kasr Al Ainy hospitals, including fifty patients undergoing elective laparoscopic cholecystectomy for symptomatic gallstones disease from November 2018 to March 2019. Scoring system of Randhawa and Pujahari had been given for each patient the day before the operation on the bases of history, clinical examination and radiological finding. Results: Prediction came true in 95% of easy cases and 77.8% of difficult cases, with no cases with score above 10. The scoring system is clinically and statistically valid test for predicting outcome in laparoscopic cholecystectomy with sensitivity 77.78 % and specificity 95.12 % with area under ROC = 0.962. Conclusion: This study shows that Ranhawa and Pujahari scoring system is reliable and could be used in Egyptian patients undergoing elective laparoscopic cholecystectomy.