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    Ahmed Qasem Mohamed,1 Essam Eldeen M.O. Mahran2
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    • Serum leptin level among Upper Egypt patients with gastroesophageal reflux disease

    Ahmed Qasem Mohamed,1 Essam Eldeen M.O. Mahran2
    1Department of Gastroenterology, Hepatology and Infectious diseases, Faculty of Medicine, Al-Azher University, Assiut, Egypt; 2Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut University, Egypt

    Introduction: Obesity is associated with an increased risk of esophageal disorders, including esophageal adenocarcinoma, Barrett esophagus and gastroesophageal reflux disease (GERD). Predominantly abdominal or intra-abdominal adiposity is more strongly linked with these esophageal disorders than BMI alone. Aim of the work is to assess if leptin have role in GERD. Patient and methods: total of 58 patients newly diagnosed as having GERD by upper endoscopy compared to 29 healthy volunteer as control group all are subjected to measuring BMI and serum leptin. Results: Serum leptin is increased as BMI increased and degree of GERD increased with p value 0.001. Conclusion: Positive correlation between seum leptin level, BMI and degree of GERD.

    Keywords: Obesity, Leptin, GERD.

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