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    • Combined Therapy of Mixed Hemangiomas with Systemic BetaBlockers and Pulsed Dye Laser

    Mahmoud S. Elbasiouny
    Unit of General Surgery, Department of Medical Applications of Lasers, National Institute of Laser Enhanced Sciences (NILES), Cairo University

    Background: Due to deep and superficial parts of mixed hemangioma have different characteristics the clearance may be slow or incomplete in response to pulsed dye laser (PDL) alone or propranolol alone. Methods: sixty patients presented with mixed hemangiomas treated by oral propranolol at a dose of 2 mg/kg body weight per day combined with pulsed dye laser 5-7Jcm2 over a 6-9 months period. The Treatment outcomes were clinically evaluated. Results: The combined therapy shows changes in color and softening of the hemangioma, followed by regression of their sizes. The clinically elicited color changes have been objectively proven by statistically significant color clearance (p ≤ .001). Moreover, the softening of lesions followed by the clinically elicited regression of sizes has been objectively proven by statistically significant changes at lesions' thickness (P ≤ .01) (>50% regression). Conclusions: Collectively, high efficacy and tolerance of combined treatment have been elicited. 

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