Aim of Work To address the problem of misplaced central venous catheters in the prospective of their presentation, impact on patients’ health and how were they managed. Patients and Methods This is a retrospective study of 17 consecutive patients who were presented with misplaced central venous catheter. Patients demographics, presentations, site of the central vein puncture, type of the catheter, complications if any, existing comorbid conditions, investigations and the management of the misplaced catheter were recorded. Trials of repositioning of the catheters under fluoroscopy were attempted using the available tools and technology. Results Seventeen patients (10men, 7women) were included in this study. The catheters were Mahourker (9), porta A cath (7) and permicath (1). The common misplaced sites were the opposite subclavein vein in (7) cases and right ventricle in (4) cases. The presentation varied from accidentally discovered with x-ray to a serious conditions like chest pain (myocardial infarction), severe headache, dysphagia and hoarseness of voice(due to sigmoid sinus thrombosis). Four catheters were removed from the start. Ten patients were subjected to trial of repositioning over the wire under fluoroscopy. Repositioning succeeded in eight cases and failed in the remaining two. Conclusion Misplaced catheters can occur in normal or disturbed anatomy of the venous system. Presentations of misplaced catheters varies from being accidentally discovered, catheter malfunction, to serious presentations like acute chest pain and sigmoid sinus thrombosis. Diagnosis of the misplaced catheters should be kept in mind, but the clinical judgment is not enough. The management of misplaced catheters depends on the location of the catheter, indication for central access, and clinical condition of the patient.