Background: The sequelae of conservative treatment of breast cancer are difficult to treat. Lipomodelling offers a new treatment option, consisting of transferring to the deformed breast, fatty tissue that has been meticulously harvested and prepared. We evaluated the efficacy, complications and esthetic outcomes of lipomodelling after breast cancer surgeries and the oncological safety on experimental level. Material and Methods: The study included 50 female patients undergoing delayed lipomodelling after breast cancer surgery using the Coleman technique. Patients, after mastectomy or breast conservative surgery with tissue defect and/or deformities, will undergo delayed lipomodelling at least 6 months after completion of radiotherapy. Experimental study on Balb C white female mice, included lipofilling after mastectomy of induced breast cancer. Results: Sixty five sessions were carried out on 50 patients from September 2013 to June 2015.The mean of total amount of pure fat injected was 179.31 ± 99.17 ml for all sessions. The mean follow up duration was 15.38 ± 5.37 months. Complications were minimal; mainly fat necrosis after 15 sessions. Local recurrence occurred in one case. Patients’ and doctor satisfaction were evaluated and esthetic outcomes were assessed by the BCCT.core (Breast Cancer Conservation Treatment. cosmetic results) software program. On experimental pre-clinical study, no local recurrence occurred in Balb C mice in all lipofilling specimens excised after mastectomy for breast cancer. Conclusion: Lipomodelling of the breast is safe, simple, cheap and feasible technique with low rate of complications and does not affect the radiological follow up after breast cancer surgery. Keywords: Breast cancer, Lipomodelling, Local recurrence, Coleman’s technique.