Background: Revision bariatric surgery has become common due to postoperative weight gain or failure to lose adequate weight as seen more frequently following Roux-en-Y gastric bypass (LRYGB) after longterm follow-up. Patients and methods: Patients who underwent RYGB and needed a revision surgery for weight regain or failure to lose weight, were selected and underwent their surgery at the Department of General Surgery at Ain Shams University hospitals in the period from April 2014 to May 2016. Twenty four patients (24) fulfilled the entry criteria of the study. Data collection included the surgical technique, the postoperative assessment, postoperative morbidity and mortality, excess weight loss, body weight and body mass index and it was statistically analyzed. Results: Data was collected postoperatively. The mean operative time and hospital stay were 108.1±28 min (range: 74-186 min.) and 3 days (range: 2-18 days), respectively. Postoperative mean excess weight loss (%EWL) was 33.4% (range: 23-65%) and BMI was 33.9±5.1kg/m2 with no mortality reported. The overall complication and reoperation rates were 16.6% and 8.3% respectively. Conclusion: Revision LPR following RYGB for weight regain or failure to lose weight adequately, is a safe and effective procedure for weight reduction. Key words: Revision bariatric surgery, roux-en-Y gastric bypass, pouch reduction.