Objectives: The aim of this study is to compare between the short term results and healing rates between platelet rich plasma and standard four layer compression technique for treatment of chronic non ischemic venous leg ulcers (VLUs). Patients and method: From October 2015 till October 2017, 73 ulcers in 68 patients from the attendees to Zagazig university hospitals were assigned in two groups, group (A) including 42 ulcers managed by standard four layer compression therapy only and group (B) including 31 ulcers managed by four layer compression therapy and PRP. Time for complete epithelization and pain scale were followed every week. RESULTS: complete epithelization occurred in 19/36 ulcers (52.7%) and 18/27 ulcers (66.6%) in group A and B respectively after 12 week (p value=0.014). Visual analogue scale (VAS) mean values showed no statistical difference between both groups before (p value = 0.64) or after (p value = 0.114) enrollment in the study. Conclusion: PRP is feasible and safe adjunctive therapy in the management of chronic venous leg ulcers and when the technique is used in combination with multiple layer compression therapy it improves significantly both the rate of ulcer healing and pain reduction. Keywords: venous, ulcer, Platelet, plasma, compression.