Background: Although some studies shows the effect of steroids on tissue trauma after haemorrhoidectomy, still more information is needed in order to evaluate the anti-inflammatory activity of steroids administeredto prevent and decrease pain and odema in patients who underwent haemorrhoidectomy. Methods: The study was performed on 40 patients, under general anaesthesia. Patients weredivided randomly into two groups (twenty patients in each group); the first group received a four 250 mg doses of methylprednisolone, the second group received a placebo. A verbal categorical scale was used to evaluate postoperative pain (for pain intensity, none = 0, mild = 1, moderate = 2 and severe = 3). Post-operative analgesia requirements (intra-muscular morphine sulphate)additionally, blood samples were taken for the evaluations of C-reactive protein(CRP), white blood cell (WBC) and erythrocyte sedimentation rate (ESR) on the same days. A secondary aim of the study was to determine if methylprednisolone would increase the incidence of postoperative wound complications. Results: Clinically and statistically significant difference was observed in the decrease of bothpain and oedema, between the placebo and corticosteroid groups,which is effective to prevent and to decrease both pain and oedema in haemorrhoidectomy. CRP was the most sensitive acute phase reactant among CRP, ESR andWBC. No complication was observed due to steroid usage. Keyword: haemorrhoidectomy. Methylprednisolone, pain.