Ahmed Abd Al Aziz, MD1, Nader Sh. Zaki, MD2,Karim G. Moustafa, MD3, M. Fathy Elshaal
Abdrabou N Mashhour, Haitham S.E. Omar, Ramy S. Abdelkader.
Hany MS Mikhail, Mohamed M Raslan, Mohamed Y Elbarmelgi, Ramy S. Abdelkader
Adel Morad Abdallah (M.D.)
Ahmed S.M. Omar, MD
H. Said1, Ahmed Khalil1, Ahmed Fathy Hilal2
Ragai S. Hanna1, George Abdelfady Nashed2, Gamal A Makhlouf 3, Nahed A Makhlouf 4, Manal El Sayed Abdelmooty 5
Ragai S. Hanna1 , George Abdelfady Nashed2,Ashraf, A Helmy 3, Gamal A Makhlouf4, Emad Z.K. Said5, Abdelraouf MS Abdelraouf 6
Ramy Mikhael Nageeb1, *, MD, and Shaban M. Abdel Mageed2, *, MD
Shawki M.K Sharouda1*; Ramy Mikhael Nageeb2*; MD and Shaban M. Abdel Mageed1*, MD
Sherif Abdel Halim MD, MRCS, Hanna Habib MD, Hossam Elsadek MD
Ahmed Morad, MD; Wael A Jumuah, MD; Hanna Habib, MD
Yasser El Ghamrini, MD. Karim Sabry Abdel Samee, MD, MRCS(Ed), Wael Abdel Aziem Gumuah, MD.
Anas Mashal MD; Abdallah Magdy MD,FRCS
Anas Mashal MD, *Abdallah Abdelwahed MD;**Hady Saleh Abou-Ashour, MD,MRCS
The Effectiveness of Combined Wound and Intraperitoneal Local Anesthesia as Pain Relief in Laparoscopic Cholecystectomy: Prospective Case Control Study
Background: Postoperative pain is the main obstacle for safe rapid recovery of patients undergoing
laparoscopic cholecystectomy (LC).Aim of the work: To evaluate the efficacy of Levobupivacaine when
injected incisionally and intraperitoneally at the end of the LC. Methods: A total of 220 patients, subjected
to elective LC, were divided into four Groups. Group I “control” received normal saline both
intraperitoneal and at incision site. Group II received Levobupivacaine both intraperitoneal and at
incision site. Group III received incisionalLevobupivacaine only. Group IV received intraperitoneal
Levobupivacaine only. Dynamic pain by a visual analogue scale (VAS) and cumulative analgesic
consumption at 1 h, 6 h, 24 h postoperatively, as well as incidence of side-effects over 48 h after LC was
recorded. Results:Compared with those in Group I, the dynamic VAS score (VAS-D) 1 h and 6 h and 24h
postoperatively, cumulative Pethidine consumption zero, 25g and 50g, and duration of hospital stay in
Group II were less (P<0.05 for each). Furthermore, intraperitoneal and incisionalLevobupivacaine exerts
more powerful analgesic effect than single usage with intraperitoneal or incisionalLevobupivacaine
(P<0.05). Signs of local anesthetic toxicity did not occur. Conclusions:Levobupivacaine when injected
incisionally and intraperitoneallyat the end of the LC was foundeffective and safe to reduce postoperative
pain intensity.
Keywords: Laparoscopic Cholecystectomy;Levobupivacaine; Intraperitoneal and Incisional; Pain.