Introduction: Abdominoplasty is one of the most commonly performed aesthetic operations nowadays. The most common indication for abdominoplasty in general surgery is a patient with redundant skin and rectus muscle diastasis or abdominal wall hernia but without morbid obesity. Aim of the study: To assess the outcome of using harmonic scalpel in dissection during abdominoplasty in comparison to the use of monopolar diatheramy. Patients and methods: A prospective randomized single blinded controlled study was conducted in the period from June 2014 to December 2015 consisting of 30 female candidates for abdominoplasty. Patients were divided in 2 groups; group A contained 15 patients underwent abdominoplasty using harmonic scalpel for dissection and group B consisted of 15 patients who underwent abdominoplasty with electrodissection employing spray-coagulation. Results: seroma was significantly lower in group A otherewise there was no significant difference between the 2 groups in terms of intraoperative data and intra-operative complications. The short-term postoperative specific and general complication rates showed no significant difference. Conclusion: Both harmonic scalpel and monopolar electrocautery are effective methods for dissection in abdominoplasty, yet due to the high cost of harmonic scalpel, we recommend the use of monopolar eletrocautery in dissection during abdominoplasty. Disclosure: This article is not sponsored by any company, so the authors have no competing interests as defined by Nature Publishing Group, or other interests that might be perceived to influence the results and/or discussion reported in this article. Keywords: Abdominoplasty, harmonic scalpel, electrodissection, monopolar electocautary.