This prospective study included 43 patients presented to the vascular surgery department in Kasr Al Aini and New Kasr Al Aini teaching hospitals with critical lower limb ischemia between September 2011 and May 2013. The patients' age ranged between 50 and 94 years with a mean of 64. 84 years. There were fourteen females and twenty-nine males. All males were cigarette smokers and the females were not. All patients were diabetics, thirty four hypertensive (79%), four patients with atrial fibrillation (AF) (9%), four with old cerebrovascular stroke (9%), and eleven patients with coronary heart disease (25%), only one patient has end stage renal disease on regular dialysis (0.02%). All patients presented with critical limb ischemia (CLI); Rutherford (5&6). Technical success was achieved in 40 cases. One patient died postoperative because of extensive myocardial infarction. In the first three months follow up three patients had below knee amputation. Two patients died mostly of cardiac event in the second 3 months follow up. Clinical success was definitive with regaining pulse in 28 patients and clinical improvement (good capillary circulation and relief of pain) in 11 patients. The limb salvage in this study was 79.06 % after 3 months that dropped to 62.6% by the end of the one year follow up. Between 3-6 m follow up there were two more mortalities and one major amputation. By the end of the one-year follow up, the total mortalities were seven and major amputations were nine cases. Conclusion: Angioplasty alone with the development of low profile wires, and long low profile alone can be the sole treatment of infrapopliteal disease and limb salvage especially with comorbid patient and short life expectancy. The endovascular therapy has less patient burden with short hospital stay and return to normal life. Key words: Angioplasty-infrapopliteal –critical limb ischemia.