Aim of Study: We describe our vascular center experience in thromboectomy of extensive iliofemoral deep venous thrombosis by using PMT with or without thrombolytic agents in combination with venoplasty and stenting for underlying venous lesions at the same session. Methodology: Over 24 months 14 patients with extensive lower extremity DVT were treated with PMT with the AngioJet thromboectomy device in combination with lytic agent (tissue plasminogen activator or reteplase) added to the infusion in selected delayed cases. Venoplasty and venous stenting by using sinus venous stents (Optimed stent) were deployed in all cases with underlying venous stenosis in the same session of the intervention. The primary end point was angiographic evidence of restoration of venous patency at completion of the procedure. Complications, recurrent ipsilateral DVT, and improvement in clinical symptoms were evaluated. Results: Complete thrombus removal was obtained in 9 procedures (64%), and partial resolution in the remaining 5 procedures (36%). In the 5 procedures with partial resolution, rheolytic thromboectomy with thrombolysis carried out. Additional catheter-directed thrombolysis was done for 12 hours in three of these five cases. Occlusive lesions by external mass compression responsible for acute DVT were revealed in 2 patients (14%). Underlying venous stenosis was detected in 9 patients (64%) and balloon angioplasty alone without stenting was performed in one patient and the remaining 8 patients required stenting. 16 stents were deployed in these 8 patients (average two stents for the patient). Overall, immediate (<24 hours) improvement in clinical symptoms was noted in 14 patients (100%). There was only patient (1/14, 7%) suffered of generalized bleeding and retroperitoneal hematoma from the thrombolytic agent otherwise no major complications related to either PMT or the short duration of lytic agent infusion. 2 patients developed access sites minor hematoma, 5 patients developed haemoglobinuria & one patient developed severe bradycardia during the procedure. Only one patient had a recurrent thrombosis after thromboectomy by 7 months and was treated by anticoagulation. Conclusions: Percutaneous mechanical thromboectomy by using Angiojet machine is safe and effective method for thrombus removal in early cases with extensive iliofemoral DVT.