Background: Although the first single-incision laparoscopic cholecystectomy was described in 1997 by Navarra et al., this technique has spread slowly until most recent years. One of the main problems was concern about its safety specially regards CBD injuries. However, SILC holds the promise of improving the cosmetic results, reduce post-operative pain, allow early return to work resulting in greater patient satisfaction. Patients and Methods: Forty patients with chronic calcular cholecystitis underwent laparoscopic cholecystectomy. Twenty patients were subjected to SILC and were compared to the other twenty patients subjected to MILC concerning feasibility, operative time, occurrence of complications, degree of port-site pain, duration of hospital stay and finally, the aesthetic results. Results: At first, the operative time for SILC was considerably longer but later, it became almost comparable to that of MILC. CBD injury occurred in one case in the SILC group and the hepatic artery was injured in another case. Pain was significantly lower and this had resulted into lower analgesic demands and into shorter hospital stay. No port-site hernias were reported in the two groups. Finally, most of the cases in the SILC group were very satisfied with the aesthetic results. Conclusion: SILC was found to be safe, feasible, quite reproducible and had allowed early return to work through less pain and shorter hospital stay, and it had definitely resulted in better aesthetic results. However, SILC was found to be more expensive due to requiring single-use specialized instruments to complete the task safely. Key Words: Single-port, Cholecystectomy, Laparoscopic, Scarless, Single-incision, Minimally Invasive.